Premier League round-up as Arsenal, Aston Villa and Tottenham Hotspur land huge wins
Elsewhere in the capital, Tottenham Hotspur claimed a rare and significant success at Stamford Bridge, defeating Chelsea 2-0 in a fixture that concluded with the hosts reduced to ten men following Cole Palmer's exit from the pitch for a second yellow card.
At the Emirates Stadium, the Gunners secured all three points against the Toffees thanks to strikes from their backline.
Ezri Konsa opened the scoring with his maiden goal since joining the club from Villa, providing Arsenal with the breakthrough they needed against a stubborn visiting side.
Gabriel added the second to seal the victory and ensure the North London side would finish the day on equal footing with the reigning champions at the summit.
The result means Arsenal capitalised fully on City's slip-up in the Midlands, putting them right back in contention at the top of the table. The clean sheet also extended their defensive solidity at home, whilst David Moyes' squad's search for an away win continues.
At Villa Park, City experienced their first setback of the season as the home side claimed a memorable 2-1 win.
Nicolas Jackson proved to be the hero for the Villans, netting twice to secure the points and inflict the Cityzens' opening league defeat of the campaign.
The brace from the Senegal forward was enough to overcome Enzo Maresca's team, despite Erling Haaland finding the net.
The victory represented the Europa League champions' fourth win on the bounce across all competitions, highlighting their impressive form in recent weeks.
For City, the loss marks the first blemish on what had been an impeccable start to their title defence, with their 100 per cent winning run this season firmly consigned to history.
In West London, Tottenham completed a historic afternoon with their 2-0 triumph over Chelsea, marking just their second success at Stamford Bridge since 1990.
The visitors' victory was aided by the hosts being reduced to ten players when Palmer was dismissed.
The result will be particularly sweet for Spurs supporters given the rarity of their success at this particular venue over more than three decades.
Elsewhere on Saturday, Fulham maintained their positive momentum with back-to-back Premier League victories, edging past Coventry City thanks to Oscar Bobb's late intervention.
The midfielder struck ten minutes from time to secure all three points at the at the Coventry Building Society Arena for the West London outfit, continuing their recent upturn in form.
And yesterday, Ipswich midfielder Julian Enciso's equaliser cancelled out Nottingham Forest defender Neco Williams' goal, with the game at Portman Road ending 1-1.
