Tottenham Hotspur vs Villarreal: Predictions, Betting odds, Lineups, Preview

Spurs and Villareal tipped to play out an enthralling 2-2 draw
Tottenham have only conceded one goal in the Premier League this season
Former Arsenal man Nicolas Pepe will look to hurt his former rivals
Explore Bwin’s detailed preview for Tottenham Hotspur vs Villarreal in the Champions League. Stats, odds, predictions, and lineups for the 20:00 BST match.
Match Details
Fixture: Tottenham Hotspur vs Villarreal
Date: Tuesday, 16 September 2025
Kick-off: 20:00 BST
Venue: Tottenham Hotspur Stadium
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Our predictions for Tottenham Hotspur vs Villarreal
Match Prediction: Tottenham Hotspur 2-2 Villarreal
Tottenham Hotspur's recent form suggests a team capable of high performance, as evidenced by their victories over Manchester City and West Ham. Their ability to score against strong opposition could be crucial against Villarreal, who have shown vulnerability defensively in their last few games. However, their loss to Bournemouth indicates potential inconsistency that Villarreal might exploit.
Villarreal have demonstrated a strong attacking prowess, particularly in their home win against Girona. Their ability to score multiple goals could challenge Tottenham's defence, which has been strong. The match is likely to be closely contested, with both teams looking to capitalise on their offensive strengths.
Form Guide & Team Overview
Tottenham Hotspur
Tottenham's recent form has been a mix of highs and lows, with impressive wins against Manchester City and West Ham showcasing their potential. However, their loss to Bournemouth at home suggests a need for greater consistency. This inconsistency could impact their performance against Villarreal, particularly if they fail to maintain the intensity seen in their victories.
The draw against Paris Saint-Germain in the UEFA Super Cup indicates Tottenham's ability to compete against top European sides. This experience could be beneficial in the Champions League, where they will need to be at their best to overcome Villarreal's challenge.
Recent Results (all competitions):
Win: 3-0 vs West Ham (A) - Premier League
Loss: 0-1 vs AFC Bournemouth (H) - Premier League
Win: 2-0 vs Manchester City (A) - Premier League
Win: 3-0 vs Burnley (H) - Premier League
Draw: 2-2 vs Paris Saint-Germain (A) - UEFA Super Cup
Villarreal
Villarreal's recent results show a team with a potent attack, as demonstrated by their 5-0 win over Girona. This offensive strength could pose a significant threat to Tottenham's defence - even though Spurs have been strong in recent weeks.
Villareal's draw against Celta de Vigo does suggest that they can be inconsistent, particularly away from home. This inconsistency might affect their performance against Tottenham, who have shown they can be formidable at home.
Recent Results (all competitions):
Loss: 0-2 vs Atletico Madrid (A) - La Liga
Draw: 1-1 vs Celta de Vigo (A) - La Liga
Win: 5-0 vs Girona (H) - La Liga
Win: 2-0 vs Real Oviedo (H) - La Liga
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Team News & Injury Report
Tottenham Hotspur
Radu Drăgușin (Knee) - Out
James Maddison (Knee) - Out
Dejan Kulusevski (Knee) - Out
Yves Bissouma (Knock) - Doubt
Dominic Solanke (Ankle) - Doubt
Villarreal
Pau Cabanes (Knee) - Out
Gerard Moreno (Hamstring) - Out
Logan Costa (Knee) - Out
Ayoze Perez (Muscle) - Doubt
Willy Kambwala (Hamstring) - Doubt
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Lineups & Tactical Setup
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Tottenham Hotspur (4-2-3-1)
Predicted lineup: Vicario, Porro, Romero, van de Ven, Spence, Sarr, Palhinha, Johnson, Simons, Kudus, Richarlison
Tottenham's predicted lineup suggests a focus on maintaining a strong midfield presence, crucial for controlling the game's tempo against Villarreal's attacking threat.
Villarreal (4-4-2)
Predicted lineup: Junior, Mouriño, Foyth, Marín, Cardona, Buchanan, Partey, Parejo, Moleiro, Pépé, Mikautadze
Villarreal's predicted lineup indicates an emphasis on exploiting their attacking options, with the potential to overwhelm Tottenham's defence.
Key Battles & Players to Watch
Richarlison vs Juan Foyth: Richarlison's movement will be tested against Foyth’s defensive skills.
Xavi Simons vs Thomas Partey: Simons's creativity and skill will challenge Partey's defensive capabilities.
Xavi Simons (Tottenham Hotspur): Simons’ versatility and ability to influence the game from multiple positions will be key for Tottenham.
Nicolas Pépé (Villarreal): Pepe's clinical finishing and ability to create chances could be decisive for Villarreal.