The extended international break comes to a close with a big Premier League game for Tottenham Hotspur at Manchester United on Saturday.
Roberto De Zerbi and his players need to finally get their season up and running, having spent the three-week break rooted to the bottom of the Premier League table without a victory to their name in their opening five matches. Michael Carrick's United side have only won once so far and lie three points above the north London outfit in 12th.
Spurs will be heading to Old Trafford with a couple of international break concerns but also some potential returnees and the same is the case for their Manchester hosts.
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With United doing the welcoming, let's start with their doubts. Carlos Baleba could be in line to make his debut after his £70million summer move from Brighton after returning from an ankle injury and featuring in a behind-closed-doors friendly against Lausanne-Sport on Friday.
Striker Benjamin Sesko felt shin pain after the Carabao Cup match against Brighton and withdrew from the Slovenia squad so he could be a doubt for Saturday.
Patrick Dorgu went on international duty with Denmark but came off after just half an hour of their game against Wales with a thigh problem. Noussair Mazraoui faced similar on Morocco duty with a back injury that forced him off.
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Carrick is awaiting the return of Matthijs de Ligt from his long-term back injury while Amad could make his return against Spurs if he has trained with the group as the United boss hoped and both Kobbie Mainoo and Marcus Rashford withdrew from the England squad but will be hoping to feature at the weekend.
Manuel Ugarte remains out with his knee ligament injury suffered at the World Cup while goalkeepers Karl Darlow and Tom Heaton have been out with injuries during this campaign.
When it comes to Tottenham, De Zerbi will provide an update on the latest injury news surrounding Micky van de Ven and Jan Paul van Hecke at his press conference on Friday. Both suffered injuries on duty with the Netherlands, the Spurs captain hurting his hand after it was accidentally stamped on and feeling dizzy with the pain while Van Hecke suffered a toe injury in the previous game that prevented him from kicking the ball.
This game might come too early for Pedro Porro after his hamstring issue while Mykhailo Mudryk has been recovering from his ankle injury suffered in training. Wilson Odobert and Xavi Simons are working on their rehabilitation from cruciate ligament injuries but Dejan Kulusevski is closing in on a return from the complicated knee injury that has kept him out for more than 500 days.
In all there are a large number of doubts for both sides and there could yet be further with more international games still to be played before players return to London and Manchester.